New Oxadiazole Derivatives with Ag NPs :Synthesis, Characterization and Antimicrobial Screening

The new novel Oxadiazole derivatives linked to Indole moiety were prepared, and biological screened for the anti-microbial activities. These compounds (3) and (4) were obtained from many series reactions. Four steps reaction procedure was utilized that start with the first step included simple method of synthesis 2-(2-chloroacetyl) hydrazinecarbothioamide (1) from refluxing equal moles  from thiosemicarbazide and chloroacetylchloride. Compound (1) was used as the starting substance for preparing new 2-(2-(1H-indol-3-yl)acetyl)hydrazinecarbo thioamide (2) via a refluxing with Indole by using anhydrous Na2CO3 in Ethanol as a solvent. On the other hand, new Oxadiazole derivative (3) was prepared via a cyclization method of compound [2] in H2SO4. The new synthetic schiff base (4) was synthesized via condensation reaction of compound (3)  with substituted aromatic aldehyde in ethanol. Finally, the new nanocomposites based Indole moiety and oxadiazole ring coated silver nanoparticles (AgNPs) were synthesized by using silver nitrate with the final oxadiazole derivative(4). All prepared compounds and chemical structure were proved by FTIR, 1HNMR spectroscopy and colloidal (Ag NPs) it has been confirmed by XRD,SEM ,UV-Vis. Also the antimicrobial screening of the synthesized compounds against two resistant pathogenic bacteria (G+) Staphylococcus aureus , E. coli(G-) and P. aeruginosa(G-) was examined in vitro comparable with ampicillin and  cefaxim as standard antibiotic, and they exhibited positive result.