Title of article
Hair-Regrowing Potential of Minoxidil Nanocrystal Structure versus Rosemary’s Hydroethanolic Extract on C57BL/6 Mice
Author/Authors
Moradi ، Ali Department of Biology - Medical Biotechnology Research Center - Islamic Azad University, Ashkezar Branch , Seifati ، Morteza Department of Biology - Medical Biotechnology Research Center - Islamic Azad University, Ashkezar Branch , Darroudi ، Majid Department of Medical Biotechnology and Nanotechnology - Nuclear Medicine Research Center, Faculty of Medicine - Mashhad University of Medical Sciences , Golmohammadzadeh ، Shiva Department of Pharmaceutics - Nanotechnology Research Center, Pharmaceutical Technology Institute, Faculty of Pharmacy - Mashhad University of Medical Sciences , Dehghani Ashkezari ، Mahmood Department of Biology - Medical Biotechnology Research Center - Islamic Azad University, Ashkezar Branch
From page
90
To page
102
Abstract
This study aimed to enhance the effectiveness and water solubility of Minoxidil (MXD) by producing its nanocrystal structure, which improves its vasodilator properties and promotes hair growth. In the current study, the hair growth-stimulating activity of the MXD nanoparticles (MXD-NPs) was compared with the hydroethanolic rosemary (RSY) extract on the C57BL/6 mice. The MXD-NPs were produced through a bead mill and ultrasonic process and characterized using various techniques. The cytotoxicity of MXD-NPs was studied on human dermal fibroblasts, and their hair growth-stimulating activity was analyzed in C57BL/6 mice. The results showed that MXD-NPs significantly increased the hair growth rate in mice compared to commercial MXD and hydroethanolic rosemary extract as they were delivered safely and specifically to the target pilosebaceous follicles. The follicular uptake of MXD-NPs was also increased compared to commercial MXD, leading to improved pilosebaceous follicle re-growth and hair growth in treated mice. Therefore, MXD-NPs have the potential to be a safe and efficient iso-formulation structure for hair growth promotion.
Keywords
Minoxidil nanoparticles (MXD-NPs) , Human dermal fibroblast (HDF) , Cytotoxicity , C57BL , 6 mice , Hair growth stimulating activity
Journal title
Nanomedicine Research Journal
Journal title
Nanomedicine Research Journal
Record number
2775037
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