Stereoselective Preparation of (alpha)-Hydroxycarboxamide by Manganese Complex Catalyzed Hydration of (alpha),(beta)-Unsaturated Carboxamide with Molecular Oxygen and Phenylsilane

Aerobic oxidation with the combined use of phenylsilane and a manganese complex catalyst was successfully applied to the (alpha),(beta)unsaturated carboxamide containing a C2-symmetrical chiral auxiliary to afford the corresponding (alpha)-hydroxycarboxamide in good-to-high yield with high stereoselectivity.