Global optimization in design and control of chemical process systems

This paper presents an overview of the recent advances in deterministic global optimization approaches and their applications in the areas of Process Design and Control. The focus is on global optimization methods for (a) twice-di€erentiable constrained nonlinear optimization problems, (b) mixed-integer nonlinear optimization problems, and (c) locating all solutions of nonlinear systems of equations. Theoretical advances and computational studies on process design, batch design under uncertainty, phase equilibrium, location of azeotropes, stability margin, process synthesis, and parameter estimation problems are discussed.