Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography Original Research Article

Objectives The purpose was to examine the cardioprotective effects of recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig) in ischemia-reperfusion injury by real-time myocardial contrast echocardiography (MCE). Background P-selectin mediates leukocyte recruitment into areas of inflammation. Methods Sixteen pigs underwent 45 min of left anterior descending coronary artery occlusion followed by reperfusion and received rPSGL-Ig or vehicle. To assess changes in myocardial perfusion (A × β), MCE was performed. Results After 120 min of reperfusion, A × β in the risk area was higher (0.84 ± 0.15 dB/s vs. 0.28 ± 0.1 dB/s, p < 0.0001), and the infarct size was lower (30.3 ± 12% vs. 57 ± 14%, p = 0.002) in the rPSGL-Ig group compared with the vehicle group. Conclusions Recombinant PSGL-Ig improved postischemic reflow accurately detected by real-time MCE.