Sensory perineuritis presented as a mononeuritis multiplex associated with livedo vasculitis

We report a 52-year-old patient affected by a mononeuritis multiplex and livedo vasculitis. Sural nerve biopsy showed mild thickening of the perineurium, vascular alterations with inflammatory cell infiltration in the perineurium, and remarkable loss of large and small myelinated fibers. A therapeutic trial of acetylsalicylic acid, danazol, and dipyridamole controlled the skin lesion without improvement of nerve conduction studies.