Successful treatment of relapsing neuro-Sweetʹs disease with corticosteroid and dapsone combination therapy

Sweetʹs disease with central nervous system involvement, tentatively named neuro-Sweetʹs disease, has rarely been reported. Although systemic corticosteroid therapy is highly effective for neurologic symptoms in neuro-Sweetʹs disease, relapse is common. Here, we describe the case of a 38-year-old Japanese man who presented with relapsing neuro-Sweetʹs disease that was successfully treated with a combination of corticosteroid and dapsone. Dapsone should be considered as a therapeutic option for neuro-Sweetʹs disease patients showing relapse.