Title of article
Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization
Author/Authors
Constantine D. Tsoukas، نويسنده , , Juris A. Grasis، نويسنده , , Keith A.، نويسنده , , Ching، نويسنده , , Yuko Kawakamiand، نويسنده , , Toshiaki Kawakami، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
4
From page
17
To page
20
Abstract
Itk/Emt, a tec family tyrosine kinase, is important for T-cell development and activation through the antigen receptor. Here, we review data suggesting that Itk/Emt is involved in the generation of critical second messengers (Ca2+, PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.
Journal title
Trends in Immunology
Serial Year
2001
Journal title
Trends in Immunology
Record number
468162
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