Title of article
Synthesis and anticonvulsant activity of two N-(2,6-dimethylphenyl)pyridinedicarboximides
Author/Authors
Christine Bailleux، نويسنده , , L Vallee، نويسنده , , J.P. Nuyts، نويسنده , , J Vamecq، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
75
To page
78
Abstract
Two N-(2,6-dimethylphenyl)pyridinedicarboximides were synthesized and evaluated for anticonvulsant properties and neurotoxicity. These compounds were mainly active against maximal electroshock (MES) induced seizures in animal models. In rats dosed orally, N-(2,6-dimethylphenyl-2,3-pyridinedicarboximide 1 exhibited an anti-MES ED50 of 54.2 μmol/kg and a protective index (PI = TD50/ED50) superior to 27.4. In mice dosed intraperitoneally, compound 1 is less active against MES induced seisure (ED50 = 160.9 μmol/kg) and more neurotoxic as evidenced by a low protective index (1.93). Comparison with published data on phenytoin reveals that compound 1 is, in rats dosed orally, two-fold more potent than this antiepileptic drug against MES induced seizures.
Keywords
N-{2.6-dimethylphenyI)pyridinedicarboximides I anticonvulsant activity I neurotoxicity
Journal title
Biomedicine and Pharmacotherapy
Serial Year
1995
Journal title
Biomedicine and Pharmacotherapy
Record number
476516
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