Haemostatic system parameters in type 1 (insulin-dependent) diabetes mellitus, with and without microangiopathy.

Diabetes mellitus is associated with macro- and microangiopathic complications. The presence of haemostatic abnormalities has long been investigated without consistent results. We investigated different stages in the haemostatic process (platelet, coagulation, anticoagulation, and fibrinolytic phases) in 15 type 1 insulin-dependent diabetic (IDDM, mean age 37±10, mean±sd, years) patients, 6 without and 9 with diabetic microvascular complications at retinal and/or renal sites, including background or proliferative retinopathy and incipient nephropathy (20