Clinical characteristics determining the mode of presentation in patients with acute coronary syndromes

Objectives. The purpose of this study was to examine clinical characteristics of patients with acute coronary syndromes to identify factors that influence the mode of presentation. Background. In acute coronary syndromes, presentation with myocardial infarction or unstable angin has major prognostic implications, yet clinical factors affecting the mode of presentation are not well defined. Methods. prospective cohort study was made of 1,111 patients with acute coronary syndromes. Baseline demographic, clinical and biochemical dat were compared in groups with myocardial infarction (n = 633) and unstable angin (n = 478). Results. The risk of myocardial infarction relative to unstable angin was increased by age >70 years (odds ratio [OR] 2.21; 95% confidence interval [CI] 1.33 to 3.66), male gender (OR 1.56; CI 1.13 to 2.16) and cigarette smoking (OR 1.49; CI 1.09 to 2.03). rise in admission creatinine from the 10th to the 90th centile of the distribution also increased the odds of myocardial infarction (OR 1.30; CI 1.05 to 1.94). Conversely, the risk of myocardial infarction relative to unstable angin was reduced by previous treatment with aspirin (OR 0.37; CI 0.27 to 0.52), hypertension (OR 0.64; CI 0.47 to 0.86) and previous acute coronary syndromes (OR 0.36; CI 0.26 to 0.51) and revascularization procedures (OR 0.36; CI 0.21 to 0.62). Conclusions. The clinical presentation of acute coronary syndromes may be influenced by various factors that have the potential to influence the coagulability of the blood, the collateralization of the coronary circulation and myocardial mass. Myocardial infarction is favored by cigarette smoking, advanced age and renal impairment, while unstable angin is favored by treatment with aspirin, hypertension, previous revascularization and previous coronary syndromes.