Title of article
The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma
Author/Authors
Ahmet Gürel، نويسنده , , Nazan Tomac، نويسنده , , H. Ramazan Yilmaz، نويسنده , , Ibrahim Tekedereli، نويسنده , , Omer Akyol، نويسنده , , Ferah Armutcu، نويسنده , , Huseyin Yuce، نويسنده , , Haluk Akin، نويسنده , , Nurten Ozcelik، نويسنده , , Halit Elyas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1117
To page
1120
Abstract
Background:
We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma.
Methods:
Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV.
Results:
No significant difference in genotype frequencies was found between patients and controls.
Conclusion:
These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.
Keywords
asthma , polymorphism , oxidative stress , manganese superoxide dismutase
Journal title
Clinical Biochemistry
Serial Year
2004
Journal title
Clinical Biochemistry
Record number
482639
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