• Title of article

    Neurological manifestations of knockout mice with β-galactosidase deficiency

  • Author/Authors

    Junichiro Matsudaa، نويسنده , , Osamu Suzuki، نويسنده , , Akihiro Oshima، نويسنده , , Atsuo Ogura، نويسنده , , Masaharu Naiki، نويسنده , , Tadatoshi Furukawa and Yoshiyuki Suzuki، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1997
  • Pages
    2
  • From page
    19
  • To page
    20
  • Abstract
    We succeeded in producing the β-galactosidase-deficient knockout mouse by gene targeting in embryonic stem cells. The mutant mice developed progressive spastic diplegia within a few months after birth, and died of emaciation at 7–10 months of age. This is an authentic murine model of human GM1-gangliosidosis, and is useful for studies of its pathogenesis and treatment.
  • Keywords
    Galactosidase , GMl-gangliosidosis , animal model , Gene targeting
  • Journal title
    Brain and Development
  • Serial Year
    1997
  • Journal title
    Brain and Development
  • Record number

    493902

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=493902