Three malformation complexes related to neural crest development

We present an individual with three distinct malformation complexes, DiGeorge syndrome, CHARGE association and Dandy–Walker malformation. An extensive literature review has shown that DiGeorge syndrome and CHARGE association rarely occur simultaneously. The presence of both these malformation complexes with Dandy–Walker malformation has not been previously reported. These three malformation complexes may all be related by neural crest maldevelopment.