Title of article
A highly stable and selective biosensor using modified nicotinic acetylcholine receptor (nAChR)
Author/Authors
Mete Eray، نويسنده , , Numan S. Dogan and Ercument Arvas ، نويسنده , , Steven R. Reiken، نويسنده , , Himawan Sutisna، نويسنده , , Bernard J. Van Wie، نويسنده , , Alan R. Koch، نويسنده , , David F. Moffett، نويسنده , , Moris Silber، نويسنده , , William C. Davis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
183
To page
188
Abstract
Methods for developing stable, sensitive and selective bilayer lipid membrane (BLM)-based biosensors are discussed. Stable BLMs were formed over micromachined polyimide apertures. Selective sensors were made by incorporating nicotinic acetylcholine receptors (nAChRs) modified with bispecific antibodies (BsAbs). When two BsAbs, attached to one nAChR, encounter antigen (Ag), channels are blocked. Sensitivity to single Ag molecules would be possible by monitoring closure of individual nAChRs.
Keywords
Bilayer lipid membranes , Microfabrication , Biosensor , Modified nicotinic acetylcholinereceptor , Bispecific antibodies
Journal title
BioSystems
Serial Year
1995
Journal title
BioSystems
Record number
497162
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