Title of article
Myeloid differentiation (MyD) primary response genes in hematopoiesis
Author/Authors
Dan A Liebermann، نويسنده , , Barbara Hoffman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
16
From page
213
To page
228
Abstract
Myeloid differentiation (MyD) primary response and growth arrest DNA-damage (Gadd) genes comprise a set of overlapping genes, including known (IRF-1, EGR-1, Jun) and novel (MyD88, Gadd45a MyD118/Gadd45b, GADD45g, MyD116/Gadd34) genes, that have been cloned by virtue of being coordinately induced upon the onset of terminal myeloid differentiation. This review delineates the role MyD genes were found to play in blood cell development, where they function as positive regulators of terminal differentiation, lineage specific blood cell development, and control of blood cell homeostasis, including growth inhibition and apoptosis.
Keywords
MyD88 , MyD118 , GADD45 , Gadd34 , Apoptosis , Egr-1 , IRF-1 , Jun , Hematopoiesis , MyD116
Journal title
Blood Cells, Molecules and Diseases
Serial Year
2003
Journal title
Blood Cells, Molecules and Diseases
Record number
498666
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