Title of article
Immunoglobulin kappa gene repertoire and somatic hypermutation patterns in follicular lymphoma
Author/Authors
Tatjana Smilevska، نويسنده , , Eugenia Tsakou، نويسنده , , Anastasia Hadzidimitriou، نويسنده , , Vasilis Bikos، نويسنده , , Niki Stavroyianni، نويسنده , , Nikolaos Laoutaris، نويسنده , , ?thanasios Fassas، نويسنده , , Achilles ?nagnostopoulos، نويسنده , , Theodora Papadaki، نويسنده , , Chrysoula Belessi، نويسنده , , Kostas Stamatopoulos، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
215
To page
218
Abstract
Immunoglobulin kappa gene usage and somatic mutation patterns were studied in a series of 47 IGKV-J rearrangements amplified in 42 follicular lymphoma (FL) cases. The IGKV1-39/1D-39 gene predominated and was significantly over-represented compared to normal cells, autoreactive cells or other B cell lymphomas. The impact of somatic hypermutation varied significantly; nevertheless, mutation distribution patterns indicated pressure for preservation of the B cell receptor. In conclusion, the present series demonstrates biased usage of IGKV genes in FL and alludes to the important role of immunoglobulin kappa light chains in antigen selection of the clonogenic B cells in FL.
Keywords
Follicular lymphomaImmunoglobulinKappa light chainsSomatic hypermutation
Journal title
Blood Cells, Molecules and Diseases
Serial Year
2008
Journal title
Blood Cells, Molecules and Diseases
Record number
499354
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