Title of article
Plasma GABA predicts acute response to divalproex in mania
Author/Authors
Frederick Petty، نويسنده , , A. John Rush، نويسنده , , John M. Davis، نويسنده , , Joseph R. Calabrese، نويسنده , , Susan E. Kimmel، نويسنده , , Gerald L. Kramer، نويسنده , , Joyce G. Small، نويسنده , , Marvin J. Miller، نويسنده , , Alan E. Swann، نويسنده , , Paul J. Orsulak، نويسنده , , Molly E. Blake، نويسنده , , Charles L. Bowden، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
7
From page
278
To page
284
Abstract
Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized, controlled acute phase treatment trial. Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p< .05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.
Keywords
bipolar disorder , GABA , Mania , Divalproex , lithium , Valproic acid , responseprediction
Journal title
Biological Psychiatry
Serial Year
1996
Journal title
Biological Psychiatry
Record number
499676
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