New methods to predict MHC-binding sequences within protein antigens

The identification and analysis of MHC-binding sequences within protein antigens, and ultimately the ability to predict them, is central to immunology. Recent advances have revealed increasingly complex MHC-binding motifs and allow prediction of sequences that bind to both classes of MHC molecules. The systematic characterization of binding motifs for all human MHC alleles is now possible and will facilitate the design of peptides for therapeutic intervention.