The effects of BIS-GMA and TEG-DMA on female mouse fertility

Objectives The current study evaluated the effect of bisphenol A glycerolate dimethacrylate (BIS-GMA) and triethyleneglycol dimethacrylate (TEG-DMA) on female mouse fertility. Methods Adult female mice were exposed to BIS-GMA or TEG-DMA (0, 25 and 100 μg/kg) intragastrically daily for 28 d and then mated with sexually mature untreated male mice and after mating their fertility was assessed. Results In females exposed to BIS-GMA at both doses significant increases in the total number of resorptions out of the total number of implantations were observed, with a significant increase in the number of animals with resorptions at the higher dose. Significant reductions in body weights and significant increases in ovary weights were also observed. Exposure to TEG-DMA at a dose of 100 μg/kg resulted in significant reductions in pregnancy rates and a significant increase in the total number of embryonal resorptions. Significant reductions in body and uterine weights were also observed in females exposed to TEG-DMA. Significance The results suggest that both BIS-GMA and TEG-DMA have reproductive toxic effects in female mice.