Key clinical trials in gynaecological oncology

Aims To review the most important clinical trials which have impacted the management of gynaecological cancers, in conjunction with some ongoing studies of interest. Methods PubMed and Cochrane databases were searched to find clinical trials and meta-analyses in vulva, cervical, endometrial and ovarian cancers. Other pertinent literature was also used. Results The majority of trials related to ovarian and cervical cancers, and the least associated with vulval cancer. Conclusions To ensure evidence based medicine, trials in gynaecological cancers must be supported. Notably, surgical trials are on the increase in the last decade, but are still a minority when compared with non-surgical interventions.