The role of Fas ligand in vivo as a cause and regulator of pathogenesis

Recent studies have significantly advanced our understanding of the physiological and pathogenic functions of Fas and Fas ligand (FasL) in vivo. In particular, roles for Fas–FasL interactions both in the induction and regulation of organ-specific autoimmune diseases have been defined and in some cases the specific targets and effectors of these interactions have been identified. Understanding the dynamic role of the Fas–FasL pathway in autoimmunity will provide insight into how best to modulate this interaction to achieve therapeutic benefits.