Title of article
Human genetic defects in class-switch recombination (hyper-IgM syndromes)
Author/Authors
Anne Durandy، نويسنده , , Tasuku Honjo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
6
From page
543
To page
548
Abstract
Several genetic defects in class-switch recombination, leading to hyper-IgM syndromes, have been recently described in humans. Besides the well-known role of interaction between CD40-ligand and CD40, these pathological conditions definitively demonstrate the requirement of CD40-mediated NF-κB activation and the essential role of a newly described molecule, activation-induced cytidine deaminase (AID), in B cell terminal differentiation.
Journal title
Current Opinion in Immunology
Serial Year
2001
Journal title
Current Opinion in Immunology
Record number
512115
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