Regulation of B cell fates by BCR signaling components

Recent results obtained in mice harboring cytoplasmic mutations of Igα and/or Igβ have reinforced the concept that the strength of BCR signaling is important for ensuring appropriate developmental outcomes as well as antigen-specific responses. To establish the optimal signaling intensity and duration, the BCR utilizes positive and negative regulatory molecules. Studies are beginning to reveal how these molecules maintain immunological homeostasis and tolerance.