Title of article
AID in somatic hypermutation and class switch recombination
Author/Authors
Simonne Longerich، نويسنده , , Uttiya Basu، نويسنده , , Frederick Alt، نويسنده , , Ursula Storb، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
11
From page
164
To page
174
Abstract
Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA ‘repair’ mechanisms and AID evolution.
Journal title
Current Opinion in Immunology
Serial Year
2006
Journal title
Current Opinion in Immunology
Record number
512637
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