Title of article
Reactions of copper(II)-oligopeptide complexes with hydrogen peroxide: Effects of biological reductants
Author/Authors
Jun-ichi Ueda، نويسنده , , Yoshie Shimazu، نويسنده , , Toshihiko Ozawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
5
From page
929
To page
933
Abstract
Cu(II) complexes with oligopeptides containing histidyl residue in the second or third position could scarcely activate hydrogen peroxide (H2O2), but they could activate H2O2 to yield hydroxyl radical (·OH) in the presence of biological reductants such as cysteine and ascorbic acid. Further, DNA single strand breakage was also observed during the reactions of Cu(II)-glycylglycylhistidylglycine (GGHG) with H2O2 in the presence of same biological reductants.
Keywords
Copper ion , Histidine , Oligopeptides , DNA strand breaks , glutathione , Cysteine , ascorbic acid , free radicals , OH radicals
Journal title
Free Radical Biology and Medicine
Serial Year
1995
Journal title
Free Radical Biology and Medicine
Record number
517111
Link To Document