Title of article
NMDA receptor activation: critical role in oxidant tissue injury
Author/Authors
Sami I. Said، نويسنده , , Hadayat Pakbaz، نويسنده , , Hasan I. Berisha، نويسنده , , Syed Raza، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
3
From page
1300
To page
1302
Abstract
The excitatory amino acid glutamate serves important neurologic functions, but overactivation of its N-methyl-D-aspartate (NMDA) receptor is toxic to neurons (excitotoxicity). We report that NMDA receptor blocker MK-801 (dizocilpine maleate) attenuated oxidant injury induced by paraquat or by xanthine oxidase. We conclude that excitotoxicity may be a key factor in oxidant tissue injury.
Keywords
Paraquat , oxidant stress , Xanthine oxidase , NMDA receptors , glutamate , MK-801 , Acute lung injury , free radicals , Excitotoxicity
Journal title
Free Radical Biology and Medicine
Serial Year
2000
Journal title
Free Radical Biology and Medicine
Record number
518521
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