Title of article
Actin is oxidized during myocardial ischemia
Author/Authors
Saul R. Powell، نويسنده , , Ellen M. Gurzenda، نويسنده , , Sayed Emal Wahezi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
6
From page
1171
To page
1176
Abstract
Exposure of isolated rat hearts to 30 min global ischemia followed by 60 min reperfusion resulted in a significant 80% increase (p < .05) in actin content of carbonyl groups, which was associated with significant depression (p < .05) of postischemic contractile function. This result supports the hypothesis that one mechanism of postischemic contractile dysfunction may be oxidation of contractile proteins.
Keywords
Actin , Protein carbonyls , protein oxidation , Myocardial ischemia , free radicals
Journal title
Free Radical Biology and Medicine
Serial Year
2001
Journal title
Free Radical Biology and Medicine
Record number
518837
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