Title of article
Synthesis and in vivo disposition studies of 18F-labeled HFA-134a
Author/Authors
John R. Finch، نويسنده , , William R. Banks، نويسنده , , Dah-Ren Hwang، نويسنده , , Martin R. Satter، نويسنده , , Bilal Ezzidene، نويسنده , , Joseph C. Mantil، نويسنده , , George A. Digenis، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
8
From page
241
To page
248
Abstract
A rapid synthesis of the chlorofluorocarbon replacement compound 1,1,1,2-tetrafluoroethane (HFA-134a) was identified and utilized to prepare 99 + % radiochemically pure [18F]HFA-134a in 20–35% radiochemical yield. Four rats were then exposed to no-carrier-added (NCA) [18F]HFA-134a and monitored via coincidence detection. Following withdrawal of the test atmosphere of [18F]HFA-134a, the me an half-life of [18F]HFA-134a in four rats was determined to be 7.8 ± 1.5 min following a 10 s exposure and 8.1 ± 1.7 minutes following a 10 min exposure.
Journal title
Applied Radiation and Isotopes
Serial Year
1995
Journal title
Applied Radiation and Isotopes
Record number
539206
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