Title of article
On-column preparation of 1-aminocyclopentane-1-[11C]carboxylic acid
Author/Authors
Ren Iwata، نويسنده , , Tatsuo Ido، نويسنده , , Masao Tada، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
7
From page
899
To page
905
Abstract
A new, convenient on-column method using kieselguhr (Extrelut®, Merck) has been developed for the synthesis of 1-aminocyclopentane-1-[11C]carboxylic acid ([11C]ACPC) from [11C]HCN. The whole synthetic procedure, including the trapping and reaction of [11C]HCN as well as the following extraction and acid hydrolysis, was remarkably simplified, and the preparation has been successfully accommodated to routine production of [11C]ACPC. The established method provides radiochemically pure [11C]ACPC in over 60% radiochemical yield within 40 min after the end of bombardment.
Journal title
Applied Radiation and Isotopes
Serial Year
1995
Journal title
Applied Radiation and Isotopes
Record number
539355
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