Title of article
Basic hydrolysis of image in the preparation of 2-[18F]fluoro-2-deoxy-image-glucose
Author/Authors
F. Füchtner، نويسنده , , J. Steinbach، نويسنده , , P. M?ding، نويسنده , , B. Johannsen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
61
To page
66
Abstract
In contrast to the commonly used acid hydrolysis of image to [18F]FDG, basic hydrolysis is a short, high-yield procedure at room temperature. In case of nucleophilic [18F]FDG synthesis the yield of removing the protective groups is quantitative. Using the electrophilic procedure the yield is about 20% higher than in acid hydrolysis. Under optimal conditions (0.3 M NaOH) the reaction is already completed within 1 min. In alkaline solutions the formed [18F]FDG is stable for more than 20 min. Additionally, the formation of 2-deoxy-2-chloro-image-glucose is avoided.
Journal title
Applied Radiation and Isotopes
Serial Year
1996
Journal title
Applied Radiation and Isotopes
Record number
539433
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