Title of article
Tritium labelling and characterization of the antimalarial drug (+/−)-chloroquine by several methods
Author/Authors
Judith A. Egan، نويسنده , , Anne G. Laseter، نويسنده , , Crist N. Filer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
343
To page
345
Abstract
To study its mechanism of antimalarial action, a tritium labelled analogue of (+/−)-chloroquine was required at high specific activity. Two synthetic methods were successfully employed. [3-3H] (+/−)-Chloroquine 2 was prepared by the catalytic tritium dehalogenation of an iodo precursor and [N-ethyl-3H] (+/−)-chloroquine 4 was synthesized by the alkylation of (+/−)-desethylchloroquine with [3H] ethyl iodide.
Keywords
Tritium NMR , Tritium , ??= ?-Chloroquine
Journal title
Applied Radiation and Isotopes
Serial Year
2002
Journal title
Applied Radiation and Isotopes
Record number
541310
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