Labeling and biodistribution of different particle materials for radioembolization therapy with 188Re

Radioembolization of tumors after selective catheterization has been proven to be an effective therapy in nuclear medicine. The goal of the study was to evaluate the 188Re labeling and in vitro and in vivo stability of several representative non-degradable polymeric microspheres and biodegradable particles. The biodistribution after i.v. injection in Wistar rats revealed excellent in vivo stability with low uptake in the non-target tissues over 48 h for some polymeric particles and especially for biodegradable human serum albumin microspheres.