Proteins and cyanine dyes. Part III. Synthesis and spectroscopic studies of benzothiazolo-4-[1,2,6trimethylpyridinium] monomethine cyanine dyes for fluorescent detection of bovine serum albumin in solutions

The spectral-luminescent properties of a series of new cyanine dyes as possible probes for homogeneous assay of proteins have been studied. The fluorescent cyanine dyes development was based on the principle of "affinity-modifying group" with the use of benzothiazolo-4[1,2,6-trimethylpyridinium] monomethine as template. It was shown that the cyanine dye P-5 can be used as a sensitive and specific fluorescent probe for the detection of BSA.