Reactivity of hydroxybenzoic acids in the hydrogen-isotope exchange reaction

The hydrogen-isotope exchange reaction (T-for-H exchange reaction) between tritiated water vapor (HTO vapor) and 3-hydroxy-4-methoxybenzoic acid (and itʹs analog; 4-hydroxy-3-methoxybenzoic acid) were observed at 50 and 70 °C in a gas–solid system to reveal the reactivity of a functional group in an aromatic compound having two substituents in the aromatic ring. Further, it was shown that (a) the reactivity of the compounds used in this work follows the Hammettʹs rule, and (b) the reactivity of trisubstituted aromatic compound could be analyzed by applying the additive property of the Hammettʹs rule even if the compound contains a substituent at the ortho-position.