Title of article
Preparation and biological studies of 125I-DOTA-TATE
Author/Authors
Aruna Korde، نويسنده , , Usha Pandey، نويسنده , , Sharmila Banerjee، نويسنده , , Haladhar Dev Sarma، نويسنده , , Archana Mukherjee، نويسنده , , Meera Venkatesh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
687
To page
690
Abstract
DOTA-TATE, a somatostatin analog was radiolabeled with 125I in good yields and high radiochemical purity. The product exhibited good stability in vitro. Pharmacokinetic studies in normal Swiss mice showed rapid blood clearance with low thyroid uptake. Biodistribution studies in murine melanoma showed 3.0±1.3% ID/g uptake in tumor at 3 h post injection (p.i.), with negligible reduction at 24 h p.i. Inhibition studies carried out in vivo using cold DOTA-TATE confirmed the tumor specificity of the product.
Keywords
Somatostatin receptors , Peptide receptor radiotherapy , 125I-DOTA-TATE
Journal title
Applied Radiation and Isotopes
Serial Year
2007
Journal title
Applied Radiation and Isotopes
Record number
548228
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