Title of article
Tumor immunolocalization using 124I-iodine-labeled JAA-F11 antibody to Thomsen–Friedenreich alpha-linked antigen
Author/Authors
Richa Chaturvedi، نويسنده , , Jamie Heimburg، نويسنده , , Jun Yan، نويسنده , , Stephen Koury، نويسنده , , Munawwar Sajjad، نويسنده , , Hani H. Abdel-Nabi، نويسنده , , Kate Rittenhouse-Olson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
10
From page
278
To page
287
Abstract
Clinical immunolocalization has been attempted by others with an anti-Thomsen–Friedenreich antigen (TF-Ag) mAb that bound both alpha- and beta-linked TF-Ag. In this report, 124I-labeled mAb JAA-F11 specific for alpha-linked TF-Ag showed higher tumor specificity in in vivo micro-positron emission tomography (micro-PET) of the mouse mammary adenocarcinoma line, 4T1, showing no preferential uptake by the kidney. Labeled product remained localized in the tumor for at least 20 days. Glycan array analysis showed structural specificity of the antibody.
Keywords
Radiolabeled monoclonal antibody , JAA-F11 , TF-Ag , breast carcinoma , Immunolocalization , biodistribution , Micro-PET
Journal title
Applied Radiation and Isotopes
Serial Year
2008
Journal title
Applied Radiation and Isotopes
Record number
548374
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