Title of article
Indinavir concentrations and St Johnʹs wort Original Research Article
Author/Authors
Stephen C Piscitelli، نويسنده , , Aaron H Burstein، نويسنده , , Doreen Chaitt، نويسنده , , Raul M Alfaro، نويسنده , , Judith Falloon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
2
From page
547
To page
548
Abstract
St Johnʹs wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.
Journal title
The Lancet
Serial Year
2000
Journal title
The Lancet
Record number
551001
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