Title of article
Hormone replacement therapy and serum angiotensin-converting-enzyme activity in postmenopausal women
Author/Authors
A. J. Proudler، نويسنده , , D. Crook، نويسنده , , J. C. Stevenson، نويسنده , , A. I. H. Ahmed، نويسنده , , J. M. Rymer، نويسنده , , I. Fogelman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
2
From page
89
To page
90
Abstract
The mechanisms by which hormone replacement therapy (HRT) reduces the risk of coronary heart disease (CHD) are incompletely understood, but may include direct arterial effects. We examined the effect of oestrogen/progestagen HRT on serum angiotensin-converting-enzyme (ACE) activity in postmenopausal women. After 6 months, ACE activity was reduced by 20% (p<0·001) on average in 28 treated women but remained unchanged in 16 controls. Serum ACE activity is modifiable by gonadal steroids and changes in serum ACE may represent a novel mechanism by which HRT reduces CHD risk in women.
Journal title
The Lancet
Serial Year
1995
Journal title
The Lancet
Record number
562421
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