Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population

Background In most previous epidemiological studies on the prevalence of chronic heart failure (CHF) the disorder has been defined on clinical criteria. In a cross-sectional survey of 2000 men and women aged 25–74, randomly sampled from one geographical area, we assessed left- ventricular systolic function by echocardiography. Methods 1640 (83%) of those invited took part. They completed a questionnaire on current medication, history, and symptoms of breathlessness. Blood pressure was measured and electrocardiography (ECG) and echocardiography were done. Left-ventricular ejection fraction was measurable in 1467 (89·5%) participants by the biplane Simpsonʹs rate method. Findings The mean left-ventricular ejection fraction was 47·3%. The prevalence of definite left-ventricular systolic dysfunction (defined as a left-ventricular ejection fraction ≤30%) was 2·9% overall (43 participants); it increased with age and was higher in men than in women (4·0 vs 2·0%). The left-ventricular systolic dysfunction was symptomatic in 1·5% of participants and asymptomatic in 1·4%. 83% of participants with left-ventricular systolic dysfunction had evidence of ischaemic heart disease (IHD) from history or ECG criteria compared with 21% of those without this abnormality (p<0·001). Hypertension was also more common in those with left-ventricular systolic dysfunction (72 vs 38%, p<0·001), but there was no difference between those with and without left-ventricular systolic dysfunction in the rate of hypertension without IHD. Interpretation Left-ventricular systolic dysfunction was at least twice as common as symptomatic heart failure defined by clinical criteria. The main risk factors are IHD and hypertension in the presence of IHD; screening of such high-risk groups for left-ventricular systolic dysfunction should be considered.