Effect of systemic corticosteroids on elective left-sided colorectal resection with colorectal anastomosis

Background The impact of systemic steroid therapy on surgical outcome after elective left-sided colorectal resection with rectal anastomosis is not well known. Methods We compared 606 consecutive patients including 53 patients who were on steroids and undergoing surgery between 1995 and 2005. Results Postoperative mortality and anastomotic leakage rates were equivalent. The postoperative complications rate, especially infections, was higher in steroid-treated patients than in non–steroid-treated patients: 38% (20 of 53 patients) versus 25% (139 of 553 patients), respectively (P = .046). In the steroid group, univariate analysis revealed 3 significant risk factors for postoperative complications: blood transfusion, preoperative anticoagulation, and chronic respiratory failure. In a multivariate analysis, blood transfusion and chronic respiratory failure remained independent factors for postoperative complications. Conclusion Patients on steroids have a higher incidence of postoperative complications after elective left-sided colorectal resection with rectal anastomosis.