Role of frequency doubling perimetry in detecting neuro-ophthalmic viual field defect

PURPOE: To report the ability of frequency doubling perimetry to detect “neuro-ophthalmic” field defect, characterize them a hemianopic or quadrantanopic, and differentiate glaucomatou from “other” neuro-ophthalmic field defect. METHOD: ixty eye of 30 normal ubject, 50 eye of 29 patient with glaucomatou defect, and 138 eye of 103 patient with “typical” neuro-ophthalmic field defect underwent automated perimetry uing the wedih Interactive Threhold Algorithm and frequency doubling perimetry. The enitivity and pecificity for identification of a field defect (frequency doubling perimetry 20-5 and 20-1 creening tet), or to characterize hemianopia/quadrantanopia (full threhold tet) were determined. Ability to dicriminate glaucomatou defect wa determined by comparing frequency doubling perimetry full threhold tet in glaucoma to pooled reult of normal and neuro-ophthalmic group. REULT: On frequency doubling perimetry, a ingle point depreed to le than 1% probability had a enitivity of 97.1% (20-5 tet) and 95.7% (20-1 tet) for detecting a neuro-ophthalmic viual field defect. The correponding pecificitie were 95% uing pooled reult in normal ubject and patient with glaucoma and “other” neuro-ophthalmic field defect. In 20-5 creening a ingle abnormal point depreed to le than 2% probability level had a enitivity of 98.6% (pecificity 85%). Two abnormal point in the 20-1 creening depreed to le than 1% probability level had a pecificity of 100% (enitivity 84.8%). In frequency doubling perimetry full threhold, enitivity and pecificity for detection of hemianopia were 86.8% and 83.2%; for quadrantanopia they were 79.2% and 38.6%. The enitivity and pecificity for categorizing a defect a glaucomatou were 86% and 74.7%. CONCLUION: Frequency doubling perimetry i a enitive and pecific tet for detecting “neuro-ophthalmic” field defect. The preence of two abnormal point (20-1 creening program) “rule in” the preence of a field defect. A normal 20-5 program (abence of a ingle abnormal point) almot “rule out” a defect. Frequency doubling perimetry could not accurately categorize hemianopic, quadrantanopic, or glaucomatou defect