Adenoviru detected by polymerae chain reaction in multidoe eyedrop bottle ued by patient with adenoviral keratoconjunctiviti

PURPOE: We invetigated the potential of a multidoe eyedrop bottle ued by patient with adenoviral keratoconjunctiviti a a ource for preading infection. DEIGN: Propective conecutive cae erie. METHOD: The content of multidoe eyedrop bottle given to patient with adenoviral conjunctiviti and in ue for 1 week were analyzed by polymerae chain reaction for adenoviru after a long a 9 week of preervation at room temperature. REULT: Of 26 patient with adenoviral keratoconjunctiviti, the eyedrop bottle of 19 patient (73%) were poitive for adenoviru. The maximum detection interval wa 9 week. ignificantly higher prevalence of intrafamilial infection (P = .0098) and of corneal ubepithelial opacity (P = .046) were oberved among cae with adenoviral contamination than among cae without contamination. CONCLUION: Multidoe bottle ued by patient with adenoviral keratoconjunctiviti are a poible vector for viral tranmiion for a long a 9 week.