Endothelial cell activation and hypercoagulability in ocular behçet’ dieae

Purpoe To invetigate the preence of a hypercoagulable tate and vacular endothelial dyfunction in patient with ocular Behçet’ dieae and relate the reult to the activity of ocular and ytemic involvement. Deign Cro-ectional laboratory and clinical tudy. Method Propective tudy of blood ample of 24 patient diagnoed with ocular Behçet’ dieae, which were analyzed for factor VIII, factor XI, von Willebrand factor antigen and ritocetin (vWF ag and rito), antithrombin III (ATIII), protein C and , fibrinogen and activated protein C (APC) reitance. The reult were compared with 40 healthy control and analyzed for aociation with ocular and ytemic clinical feature. Reult The mean value of factor VIII, factor XI, vWF ag, vWF rito, ATIII, and fibrinogen were ignificantly raied compared to healthy population (for all: P< .001). Mot triking were factor VIII activity level above 130% in 79% (19 of 24) of our patient. 67% (16 of 24) had level of factor VIII above 150%, which correlate with a fivefold increae in rik of thromboi. Other prothrombogenic factor were negative in all but 2 patient (1 protein C deficiency, 1 factor V Leiden mutation). Endothelial cell activation, meaured by vWF activity, revealed elevated level in 42% (10/24). Complete/incomplete Behçet’ dieae patient with preent or previou macular edema had ignificantly higher FVIII level than complete/incomplete Behçet’ dieae patient who had never hown any ign of macular edema (P = .04). Further correlation between the laboratory reult and clinical ymptom were not found. Concluion We found a generalized hypercoagulable tate with endothelial cell activation in ocular Behçet’ dieae, irrepectively of current ocular dieae activity