Decreaed level of pigment Epithelium–derived factor in eye with neuroretinal dytrophic dieae

Purpoe To determine the concentration of pigment epithelium–derived factor (PEDF) in the aqueou humor of eye with neuroretinal dytrophy. Deign Obervational cae erie. Method Aqueou humor wa obtained from patient during cataract urgery, and the PEDF concentration in the aqueou humor wa meaured by enzyme-linked immunoorbent aay. The primary diagnoi wa cataract in 162 eye; of thee there were five eye with retiniti pigmentoa, nine eye with advanced glaucoma, and 148 eye with cataract alone. Reult The mean level of PEDF in eye with retiniti pigmentoa (0.24 ± 0.04 μg/ml, mean ± E, P = .0004) and advanced glaucoma (0.46 ± 0.08 μg/ml, P = .003) were ignificantly lower than that in eye with cataract alone (0.86 ± 0.04 μg/ml). Concluion The lower level of PEDF in eye with neuroretinal dytrophy may be related to the lo of the retinal ganglion cell or retinal pigment epithelium cell that yntheize PEDF.