Plama ghrelin level are normal in obee patient with idiopathic intracranial hypertenion (peudotumor cerebri)

Purpoe Idiopathic intracranial hypertenion (IIH) occur predominantly in young, obee women. Weight lo may alleviate ymptom of IIH yet may be difficult to achieve. Ghrelin, a gatric hormone, i involved in normal body weight and appetite regulation. It level are elevated in yndrome of overeating and decline in imple obeity. We potulated that fating plama ghrelin level are elevated in IIH patient and that the typical potprandial decline in plama ghrelin may not occur. Deign Propective, obervational cae-control tudy. Method Propective tudy. etting Univerity hopital and clinic. tudy population ixty-five patient with a diagnoi of IIH and 25 obee control patient (creened for IIH ymptom). Patient with intracranial abnormalitie or a hitory of gatric urgery were excluded. Obervation procedure Fating plama ghrelin, leptin, and inulin level were aeed between 8 am and 10 am. ubject were fed a tandard breakfat, and potprandial ghrelin level were meaured 30 minute later. Reult Fating plama ghrelin level negatively correlated with body ma index in both IIH ubject (r = −.48) and control; leptin howed a poitive correlation with body ma index in both IIH (r = .59) and control. Level were not ignificantly different between the group. Potprandial ghrelin declined by 71 ± 31 (95% CI) pg/ml in the IIH group and 71 ± 35 (95% CI) pg/ml in the control group. Concluion Plama ghrelin level, both fating and potprandial, do not differ between IIH patient and obee control. Obee IIH patient hould be encouraged to loe weight and referred for medical weight lo management to maximize their chance of alleviating their ymptom.