Intravitreal Triamcinolone Acetonide for Cytoid Macular Edema in Nonichemic Central Retinal Vein Occluion

Purpoe The effectivene of intravitreal triamcinolone acetonide in the treatment of cytoid macular edema from central retinal vein occluion (CRVO) wa invetigated. Deign A noncomparative, propective, interventional cae erie. Method In a clinical practice, 18 patient were enrolled with nonichemic CRVO and cytoid macular edema. Two milligram of triamcinolone acetonide were injected into the vitreou of only one eye from each patient. The outcome meaure were 1-mm mean central retinal thickne on optical coherence tomography and viual acuity. Reult Mean duration of ymptom before urgery wa 2 month (D, 1.3 month). Ten patient required repeated injection for recurrent cytoid macular edema (mean, 1.8 injection). Mean viual acuity ignificantly improved from 20/300 to 20/166 (P = .007) at 1 month, 20/100 (P = .0005) at 2 month, 20/130 (P = .007) at 3 month, and 20/150 (P = .02) at 6 month but deteriorated again to 20/270 (not ignificant) at 12 month. There wa a ignificant improvement in retinal thickne from preentation 518 μm, to 363 μm (P = .03) at 1 month, 304 μm (P = .04) at 2 month, and 353 μm (P = .01) at 3 month but not from preentation at 6 month (mean, 383 μm) and 12 month (mean, 406 μm). Eleven patient uffered intraocular preure rie requiring intervention. Intravitreal triamcinolone acetonide did not prevent collateral circulation formation, which wa een in 10 patient. Concluion Intravitreal corticoteroid injection i very effective in revering cytoid macular edema and improving viual acuity in recent-onet nonichemic CRVO in the firt 6 month, but thi i unfortunately not utained at 1 year.