Lower Intraocular Oxygen Tenion in Diabetic Patient: Poible Contribution to Decreaed Incidence of Nuclear clerotic Cataract

Purpoe To report intraocular oxygen tenion in eye of diabetic and nondiabetic patient. Deign A propective, interventional conecutive cae erie. Method Oxygen wa meaured with an optical oxygen enor in patient who were undergoing vitrectomy. Before turning on the infuion fluid, intraocular oxygen tenion wa meaured in two location: adjacent to the len and in the mid vitreou cavity. Reult Fifty eye from 50 patient were included in the tudy. Twenty-one eye were from diabetic patient and 29 eye were from nondiabetic patient. The mean oxygen tenion adjacent to the len wa ignificantly lower in diabetic than in nondiabetic patient (8.4 ± 0.7 mm Hg v 10.7 ± 0.8 mm Hg; P < .05). imilarly, the mean oxygen tenion in the center of the vitreou cavity wa lower in diabetic than in nondiabetic patient (5.7 ±0.7 mm Hg v 8.5 ± 0.6 mm Hg; P < .001). In ubgroup analye, previou panretinal photocoagulation or cataract urgery did not affect oxygen level ignificantly in the vitreou of diabetic or nondiabetic patient. Concluion Eye from diabetic patient have ignificantly lower intraocular oxygen tenion than in eye from nondiabetic patient. Becaue oxidative damage to the len nucleu and increaed intraocular oxygen tenion have been aociated with nuclear clerotic cataract, thee finding may help explain recent report of an apparent protective effect of diabete mellitu againt nuclear clerotic cataract.