Ditinct Cytokine and Chemokine Profile in the Aqueou of Patient With Uveiti and Cytoid Macular Edema

Purpoe To invetigate the global cytokine and chemokine expreion pattern in the aqueou humor of uveiti patient and relate them to clinical feature. Deign Cro-ectional tudy. Method In 31 aqueou humor ample from uveiti patient, the concentration of mediator wa meaured by a multiplex immunoaay. Eleven control ample were included. Reult Uveiti ample had higher level of interleukin-6, interleukin-8, oluble intercellular adheion molecule, oluble vacular cell adheion molecule (VCAM), and interferon-inducible protein-10 (IP-10) than nonuveiti control. Active uveiti ample had higher level of interleukin-6, interleukin-10, interferon-γ, VCAM, regulated on activation, normal T cell expreed and ecreted (RANTE), and IP-10 than quiecent uveiti ample. Infectiou uveiti wa aociated with higher level of interleukin-10 than noninfectiou uveiti (P < .03 for all ubgroup). No ignificant difference were found between cytoid macular edema (CME) and non-CME ample. Concluion Elevated level of pecific mediator were found in active and in infectiou uveiti, but not in CME. Mediator profile might lead to a better undertanding of the pathogenei of uveiti