cientific Challenge in Potmarketing urveillance of Ocular Advere Drug Reaction Original Reearch Article

Purpoe To highlight the challenge of potmarketing urveillance for drug-related advere event in the practice of ophthalmology. Deign A retropective review of the medical literature and potmarketing urveillance databae. Method MEDLINE literature review of ildenafil-aociated or amiodarone-aociated optic neuropathy and chloramphenicol-aociated blood dycraia. Reult ildenafil, amiodarone, and chloramphenicol may all caue advere ocular event; however, the data are not concluive. Concluion Report in peer-reviewed medical journal may be proven incorrect over time. For drug-induced advere ocular event, there i little true cience after the drug reache the marketplace, o the percentage of incorrect concluion may be high. Clinician hould be wary of report of advere ocular effect until data are confirmed by multiple author over the long-term. Even o, pontaneou report from potmarketing urveillance databae may be the firt and only ignal of an advere ocular event.